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In a study evaluating the neuroprotective potential of cynomenine as well as its effect on oxidative stress and inflammation in a rat model of temporal lobe epilepsy induced by intrahippocampal kainate, it was reported that GSH production decreased, ROS and MDA levels increased and Nuclear Factor kappa B (NFB) and Tumour necrosis factor-alpha (TNF-) levels increased [87]

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doi: 10.1016/j.toxicon.2012.04.147 Undheim, Eivind A

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